August 18, 2020
We’re here to guide you through the Coronavirus pandemic. Sign up to the Life newsletter for daily tips, advice, how-tos and escapism.
The Key To Treating Covid-19 Could Be In The Nose
Loss of smell and taste is one of the three key symptoms of Covid-19 that people are urged to be aware of.  It’s pretty common – a study of 24,000 people with the virus found 25% lost their ability to smell.
Other viral infections – including different forms of coronavirus – have also been known to cause a loss of smell and taste. With the common cold, for example, people will get infected, have a blocked or runny nose and their senses will be numbed for a few days. When the symptoms disappear, their sense of smell and taste is quickly restored.
With Covid-19, people aren’t showing those classic signs of a stuffy nose but are still losing their sense of smell. And in some cases, their sense of smell and taste is being distorted even after they recover from the virus. Some may be left with permanent smell loss – although we don’t know exactly why or how many.
Experts have believed for a while now that the virus enters the nasal tissues through an enzyme called the angiotensin converting enzyme II (ACE-2) receptor – and then causes temporary damage to the smell nerves, which results in a loss of smell, and subsequently a loss of taste.
A new study published in the European Respiratory Journal makes a case for this. Scientists analysed tissue removed from 23 patients’ noses during surgery and discovered extremely high levels of ACE-2 in the area of the nose responsible for smelling.
Researchers believe the enzyme is the ‘entry point’ that allows coronavirus to get into the cells of the body and cause an infection.
And with the nose being a key route for the virus to infiltrate the body and spread, targeting this part of the body could result in more effective treatments, they said. Could a nasal spray one day stop Covid-19 in its tracks? It’s possible.The team from Johns Hopkins University School of Medicine in Baltimore in the US, analysed tissue samples from the back of the nose of 23 patients, removed during endoscopic surgical procedures for conditions such as tumours or chronic rhinosinusitis, an inflammatory disease of the nose and sinus. They also studied biopsies from the trachea (windpipe) of seven patients. None of the patients had been diagnosed with coronavirus.In the lab, the researchers used fluorescent dyes on the tissue samples to detect and visualise the presence of ACE2 under a microscope and compare levels of ACE2 in different cell types and parts of the nose and upper airway.
They found the most ACE2, by far, on the lining cells of a very specific area at the back of the nose where the body detects smells. The levels of ACE2 in these cells was between 200 and 700 times higher than other tissue in the nose and trachea, and they found similarly high levels in all of the samples, regardless of what type of condition the patient had.
Co-author and research associate Dr Mengfei Chen said: “This technique allowed us to see that the levels of ACE2 – the Covid-19 ‘entry point’ protein – were highest in the part of the nose that enables us to smell. These results suggest that this area of the nose could be where the coronavirus is gaining entry to the body.”Related... These Symptoms Could Tell Covid-19 Apart From Flu This Winter The area at the back of the nose where the body detects smells, called the olfactory epithelium, is “quite an easy part of the body for a virus to reach”, added Dr Chen. “It’s not buried away deep in our body, and the very high levels of ACE2 that we found there might explain why it’s so easy to catch Covid-19.”
Co-author Professor Andrew Lane, director of the division of rhinology and skull base surgery, added: “We are now doing more experiments in the lab to see whether the virus is indeed using these cells to access and infect the body. If that’s the case, we may be able to tackle the infection with antiviral therapies delivered directly though the nose.”
Professor Tobias Welte, an expert in pulmonary medicine and director of the Department of Pulmonary and Infectious Diseases at Hannover University School of Medicine, Germany, said the finding needs to be confirmed but it offers “possible new avenues for treating the infection”. Related... In 24,000 Covid Cases, These Were The 5 Most Common Symptoms The nose could also help us tell our symptoms apart from other illnesses this winter – like cold and flu. A study, published in the journal Rhinology, compared how people with loss of smell and taste (anosmia) from Covid-19 differed from those with other causes of upper respiratory tract infections and found smell loss was “much more profound” in Covid-19 patents.
For the study they carried out smell and taste tests on 10 Covid-19 patients, 10 people with bad colds and 10 healthy people. Distinguishing features of smell loss caused by Covid-19 included being able to breathe freely, not having a runny or blocked nose, and being unable to detect bitter or sweet tastes.“It was this loss of true taste which seemed to be present in the Covid-19 patients compared to those with a cold,” said lead researcher Professor Carl Philpott, from University of East Anglia’s Norwich Medical School.
Smell and taste tests could be developed for fast Covid-19 screening, which could be used in primary care and emergency departments, he suggested.
People who lose their sense of smell or taste are currently advised by the NHS to self-isolate for at least 10 days. 
“Although such tests could not replace formal diagnostic tools such as throat swabs, they could provide an alternative when conventional tests are not available or when rapid screening is needed – particularly at the level of primary care, in emergency departments or at airports,” said Prof Philpott.
It’s previously been suggested that the Covid-19 virus affects the central nervous system, based on neurological symptoms developed by some patients.
“Our results reflect, at least to some extent, a specific involvement at the level of central nervous system in some Covid-19 patients,” said Prof Philpott. “It is particularly interesting that Covid-19 seems to particularly affect sweet and bitter taste receptors, because these are known to play an important role in innate immunity.”Related... 9 Photos Showing What 'Covid Fingers And Toes' Can Look Like These Incredible Dogs Are Being Trained To Sniff Out Covid-19 Rashes Could Be 'Key Sign' Of Covid-19. Here's What They Look Like
Related Stories
Latest News
Top news around the world
Coronavirus Disease

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.

Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness.

Around the World

Celebrity News

> Latest News in Media

Watch It
Mario Lopez, Tiffani Thiessen react to Dustin Diamond’s cancer diagnosis | Page Six Celebrity News
January 15, 2021
x4Hz209X0eg
Why 'Bling Empire' stars were skeptical to join the Netflix reality series | Page Six Celebrity News
January 15, 2021
3oHt4Cqr1J0
Bella Thorne defends Armie Hammer against allegations | Page Six Celebrity News
January 15, 2021
W0-pu9wJVkE
Gabrielle Union Shares Romantic Video on Dwyane Wade's Birthday
January 17, 2021
WZNY1Oe4CEs
Jennifer Lopez Claps Back at Botox Claims, Denies Cosmetic Surgery
January 17, 2021
upVK1ilAgWs
Phil Spector Dies in Prison at Age 81
January 17, 2021
36NxAZVd5B4
Andrew Zimmern Says Prisoners Need Better Food, Even Capitol Rioters | TMZ
January 16, 2021
sbz0nx1qST0
L.A. County Supervisor Enraged Clinics Throw Unused Vaccines in the Trash | TMZ
January 14, 2021
Upzfh-nEbq0
Drake Returns To Working Out, Looks Great! | TMZ TV
January 14, 2021
JlKeaD2mjoA
Kevin Feige on 'WandaVision' And The Future of The Marvel Cinematic Universe on Disney Plus
January 14, 2021
9AzttR4LaWg
'Promising Young Woman' Ending Analyzed By Carey Mulligan And Emerald Fennell
January 14, 2021
Rhj2RmWVup4
Golden Globes 2021: Best Drama Series
January 13, 2021
TrTjbEY6VQU
TV Schedule
Late Night Show
Watch the latest shows of U.S. top comedians

Sports

Latest sport results, news, videos, interviews and comments
Latest Events
18
Jan
ENGLAND: Premier League
Arsenal - Newcastle United
18
Jan
ITALY: Serie A
Cagliari - AC Milan
17
Jan
ITALY: Serie A
Inter Milan - Juventus
17
Jan
ENGLAND: Premier League
Liverpool - Manchester United
17
Jan
ENGLAND: Premier League
Sheffield United - Tottenham Hotspur
17
Jan
ENGLAND: Premier League
Manchester City - Crystal Palace
17
Jan
GERMANY: Bundesliga
Bayern Munich - SC Freiburg
17
Jan
ITALY: Serie A
Napoli - Fiorentina
17
Jan
GERMANY: Bundesliga
Eintracht Frankfurt - Schalke
17
Jan
ITALY: Serie A
Atalanta - Genoa
17
Jan
ITALY: Serie A
Crotone - Benevento
17
Jan
ITALY: Serie A
Sassuolo - Parma
16
Jan
GERMANY: Bundesliga
Borussia Dortmund - Mainz
16
Jan
ENGLAND: Premier League
Fulham - Chelsea
15
Jan
ITALY: Serie A
Lazio - Roma
14
Jan
ENGLAND: Premier League
Arsenal - Crystal Palace
13
Jan
ENGLAND: Premier League
Manchester City - Brighton
13
Jan
ENGLAND: Premier League
Tottenham Hotspur - Fulham
13
Jan
GERMANY: National cup
Holstein Kiel - Bayern Munich
12
Jan
ENGLAND: Premier League
Burnley - Manchester United
12
Jan
SPAIN: La Liga
Atletico Madrid - Sevilla
10
Jan
ITALY: Serie A
Juventus - Sassuolo
10
Jan
ITALY: Serie A
Udinese - Napoli
Find us on Instagram
at @feedimo to stay up to date with the latest.
Featured Video You Might Like
zWJ3MxW_HWA L1eLanNeZKg i1XRgbyUtOo -g9Qziqbif8 0vmRhiLHE2U JFCZUoa6MYE UfN5PCF5EUo 2PV55f3-UAg W3y9zuI_F64 -7qCxIccihU pQ9gcOoH9R8 g5MRDEXRk4k
Copyright © 2020 Feedimo. All Rights Reserved.