October 15, 2020
Antiviral drug remdesivir has “little or no effect” on a hospitalised Covid-19 patients’ chances of survival, a World Health Organisation (WHO) clinical trial has suggested.
Remdesivir Has Little Or No Effect’ On Covid Patient Mortality, Says World Health Organisation
The potential Coronavirus treatment option is one of four repurposed drugs being examined under the UN agency’s large Solidarity trial that launched in March.
Randomised trials at hospitals around the world have involved remdesivir, lopinavir, hydroxychloroquine and interferon-beta 1a – looking to assess their impact on inpatient mortality.
The hydroxychloroquine and lopinavir arms of the trials were discontinued on June 20 and July 4 respectively.
In a statement provided to the PA news agency on Thursday evening, the WHO press office said results from these first four treatment options of the Solidarity trial were “unpromising”.
“The trial found that remdesivir, hydroxychloqoquine, lopinavir/ritonavir and Interferon have little or no effect on mortality for hospitalized patients,” WHO said.
“Other uses of the drugs, for example in community and pre-hospital settings, would have to be examined using different trial designs.”
It added: “For each drug in the study, the effect on mortality was disappointingly unpromising. These results were not significantly affected by the exclusion of certain countries, regions or subgroups.”
The statement was provided after the FT newspaper reported it had seen a copy of a not-yet-peer-reviewed trial study revealing the drugs had little effect on in-hospital mortality nor on how long patients stayed in hospital.
Remdesivir was one of the treatments given to US President Donald Trump after he tested positive for Covid-19 earlier this month.
It was first developed as a treatment for Ebola, and works by disrupting the virus’ ability to replicate.
Clinical trials have shown the drug cuts the duration of symptoms from 15 days to 11, but there has previously been no data on survival.
The European Commission has sealed a deal with pharmaceutical company Gilead to buy 500,000 treatment courses of remdesivir, to ensure it can be stockpiled.
WHO said that over the space of six months the Solidarity trial was “able to generate conclusive evidence on the impact the repurposed drugs had on mortality, the need for ventilation, and duration of hospital stay” – something it said could not be addressed through many smaller trials.
“Although the results for the first four treatment options evaluated were unpromising, this global platform works well and is now available to rapidly evaluate promising new treatment options,” the agency said.
WHO said the trial will continue, with its International Steering Committee deciding which arms would continue in the randomisation.
“The global platform of the Solidarity trial is ready to rapidly evaluate promising new treatment options, with nearly 500 hospitals open as trial sites,” it said.
“Newer antiviral drugs, immunomodulators and anti-Sars COV-2 monoclonal antibodies are now being considered for evaluation via the Solidarity Therapeutics trial.”
It added: “These interim results do not constitute recommendations to countries. WHO guideline committees will consider them, and all other evidence generated by major in-patient Covid-19 trials and formulate WHO recommendations.”Related... Eric Trump Says Nonexistent Covid-19 Vaccine His Dad 'Took' Worked Really 'Well' Trump Leaves Hospital As Questions Mount Over Covid-19 Condition ‘Potent’ Experimental Drug Given To Trump Being Rolled Out Across UK
Related Stories
Latest News
Top news around the world
Coronavirus Disease

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.

Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness.

Around the World

Celebrity News

> Latest News in Media

Watch It
Matt Damon talks 'Stillwater' and Getting Emotional at Cannes
July 29, 2021
8jUU6-lLnss
Mena Suvari Talks About Her New Memoir 'The Great Peace'
July 28, 2021
JHOdTJdp9gY
The Cast of Disney's 'Jungle Cruise' Talk Turning The Iconic Ride Into a Film!
July 25, 2021
IAHRi18ccNw
Soulja Boy Birthday Party Shut Down By Cops | TMZ
July 29, 2021
BvoVcxNytMg
Leslie Jordan Slams DaBaby's Homophobic Rant as Stupid, Clueless | TMZ
July 29, 2021
GaiMRRJefTI
Rep. Adam Kinzinger Says Homophobic, Racist Voicemail to Officer Fanone Should Be Heard | TMZ
July 29, 2021
mjQvVqZq6vo
Ben Affleck squeezes hits the casino on vacation with Jennifer Lopez | Page Six Celebrity News
July 30, 2021
I-qapjiQ2Pw
Alex Rodriguez & Melanie Collins hit same shops as J.Lo hours apart | Page Six Celebrity News
July 29, 2021
nHxYC9WrirA
From Kitty Spencer’s wedding to Wimbledon: Summer’s top royal style moments| Page Six Celebrity News
July 29, 2021
sSP2WWfaW7E
Scarlett Johansson Sues Disney Over "Black Widow" Release | E! News
July 29, 2021
LILPm3fiItU
A-Rod's Sexy Fail, Rihanna Trolls "RHONY" & Lizzo the Killer? -"Nightly Pop" 07/29/21 | E! News
July 29, 2021
fiwi35iqwj0
Brad Pitt's Sad Lookalike, Sidechick Code & Gator Date -"Nightly Pop" 07/29/21 | E! News
July 29, 2021
zmvHv6b-r_Q
TV Schedule
Late Night Show
Watch the latest shows of U.S. top comedians

Sports

Latest sport results, news, videos, interviews and comments
Latest Events
19
Nov
ASIAN CHAMPIONS LEAGUE: Group H
Sydney FC - Shanghai SIPG
17
Nov
UEFA NATIONS LEAGUE A: Group Stage
Spain - Germany
14
Nov
UEFA NATIONS LEAGUE A: Group Stage
Germany - Ukraine
08
Nov
ENGLAND: Premier League
Manchester City - Liverpool
08
Nov
ENGLAND: Premier League
Arsenal - Aston Villa
08
Nov
SPAIN: La Liga
Valencia - Real Madrid
08
Nov
ITALY: Serie A
AC Milan - Verona
08
Nov
ENGLAND: Premier League
West Bromwich Albion - Tottenham Hotspur
08
Nov
ITALY: Serie A
Bologna - Napoli
08
Nov
ITALY: Serie A
Genoa - Roma
08
Nov
ITALY: Serie A
Atalanta - Inter Milan
08
Nov
ITALY: Serie A
Lazio - Juventus
08
Nov
GERMANY: Bundesliga
Bayer Leverkusen - Borussia Monchengladbach
08
Nov
ENGLAND: Premier League
Leicester City - Wolves
08
Nov
GERMANY: Bundesliga
Wolfsburg - Hoffenheim
08
Nov
SPAIN: La Liga
Real Valladolid - Athletic Bilbao
08
Nov
SPAIN: La Liga
Levante - Alaves
08
Nov
SPAIN: La Liga
Real Sociedad - Granada CF
08
Nov
ITALY: Serie A
Torino - Crotone
08
Nov
SPAIN: La Liga
Getafe - Villarreal
07
Nov
GERMANY: Bundesliga
Borussia Dortmund - Bayern Munich
07
Nov
ENGLAND: Premier League
Everton - Manchester United
07
Nov
ENGLAND: Premier League
Chelsea - Sheffield United
07
Nov
SPAIN: La Liga
Atletico Madrid - Cadiz
07
Nov
SPAIN: La Liga
Barcelona - Real Betis
07
Nov
GERMANY: Bundesliga
Augsburg - Hertha Berlin
07
Nov
GERMANY: Bundesliga
Stuttgart - Eintracht Frankfurt
07
Nov
GERMANY: Bundesliga
RB Leipzig - SC Freiburg
07
Nov
ENGLAND: Championship
Rotherham - Preston NE
07
Nov
ITALY: Serie A
Parma - Fiorentina
07
Nov
ENGLAND: Championship
Watford - Coventry
07
Nov
ENGLAND: Championship
Norwich City - Swansea City
07
Nov
ENGLAND: Championship
Blackburn - QPR
07
Nov
ENGLAND: Championship
Derby County - Barnsley
07
Nov
ENGLAND: Championship
Huddersfield - Luton
07
Nov
ENGLAND: Championship
Nottingham Forest - Wycombe Wanderers
07
Nov
ENGLAND: Premier League
West Ham United - Fulham
07
Nov
ENGLAND: Championship
Sheffield Wednesday - Millwall
07
Nov
ENGLAND: Championship
Brentford - Middlesbrough
07
Nov
ENGLAND: Championship
Birmingham - Bournemouth
07
Nov
SPAIN: La Liga
Sevilla - Osasuna
07
Nov
ITALY: Serie A
Benevento - Spezia
07
Nov
ENGLAND: Premier League
Crystal Palace - Leeds
04
Nov
CHAMPIONS LEAGUE: Group stage, Group G
Ferencvaros - Juventus
04
Nov
CHAMPIONS LEAGUE: Group stage, Group G
Barcelona - Dynamo K.
03
Nov
CHAMPIONS LEAGUE: Group stage, Group A
Salzburg - Bayern Munich
03
Nov
CHAMPIONS LEAGUE: Group stage, Group D
Atalanta - Liverpool
Find us on Instagram
at @feedimo to stay up to date with the latest.
Featured Video You Might Like
zWJ3MxW_HWA L1eLanNeZKg i1XRgbyUtOo -g9Qziqbif8 0vmRhiLHE2U JFCZUoa6MYE UfN5PCF5EUo 2PV55f3-UAg W3y9zuI_F64 -7qCxIccihU pQ9gcOoH9R8 g5MRDEXRk4k
Copyright © 2020 Feedimo. All Rights Reserved.