May 12, 2021
Mixing doses of the Pfizer and AstraZeneca vaccines appears to increase the likelihood of you suffering side effects, according to preliminary data from the vaccine mixing trials. 
Revealed: Mixing Covid Vaccines More Likely To Leave You With Side Effects
Data from the University of Oxford-led Com-COV study shows more frequent mild to moderate reactions in mixed schedules compared to standard schedules where people have had two doses of the same vaccine.
We don’t yet know how mixing doses impacts the body’s immune response.What’s the aim of the study?The Com-Cov study launched in February to investigate alternating doses of the Oxford/AstraZeneca vaccine and the Pfizer/BioNTech vaccine. In April, it announced the programme would be extended to include the Moderna and Novavax vaccines. 
The aim of the trial is to explore whether the Covid-19 vaccines can be used more flexibly, with different vaccines being used for the first and second dose. This would mean if there were supply issues, alternatives could be offered. England’s deputy chief medical officer, Professor Jonathan Van-Tam, previously said it’s even possible that “by combining vaccines, the immune response could be enhanced giving even higher antibody levels that last longer” – although this is only a theory and hasn’t been proven. What did the study find?The trial recruited 830 volunteers aged 50+ from various areas in England. The study confirmed people are more likely to have side effects after the first dose of AstraZeneca than the first dose of Pfizer. It also showed people were more likely to get side effects after the second dose of the Pfizer jab, compared to the first. 
When given at a four-week interval, both of the ‘mixed’ schedules – Pfizer followed by AstraZeneca, and AstraZeneca followed by Pfizer – induced more frequent mild and moderate side effects following the second ‘boost’ dose than the standard schedules. Mild side effects were those that didn’t have much impact on study participants’ daily activities, while moderate side effects had “some impact” on their daily activities.
Both of the mixed schedules caused more symptoms than the standard schedules, particularly when it came to systemic reactions – so things like chills, fatigue, fever, headache and joint pain.
Researchers noted a possibility that side effects from mixing doses may be more prevalent in younger age groups. This is because data has so far shown that when people do suffer side effects from the vaccines, it tends to be more common in those aged 16 to 55 years old.Why are side effects more of an issue with mixed doses?In a press briefing, lead investigator on the trial Matthew Snape, associate professor in paediatrics and vaccinology at the University of Oxford, said the finding was “intriguing” and not necessarily one they were expecting. 
When asked why side effects might be more problematic with mixed doses, he suggested that these reactions often relate to the stimulating of the innate immune response which is your body’s first line of defence.
When you’re exposed to a germ (or a vaccine mimicking infection), your innate immune system kicks in to try and fight it. “These early reactions we’re seeing are more about the innate immune response sending out more of an inflammatory signal,” said Snape.What are the implications?Researchers noted that any adverse reactions from mixing doses of the vaccines were “short-lived” and there were no other safety concerns.
But Snape said it’s still important to inform people of these data, especially as mixed-doses schedules are being considered in several countries.
“One of the things it’s telling us is that you wouldn’t want to immunise a ward full of nurses on the same day with a mixed schedule because you may have higher rates of absenteeism the next day,” said Snape.What about the immune response?Researchers hope to report data on how the immune response is impacted by mixing the vaccines in the coming months. “In the meantime, we have adapted the ongoing study to assess whether early and regular use of paracetamol reduces the frequency of these reactions,” added Snape.Related...Covid Jab Side Effects Are 'Normal', Say GPs. But Here's When To Seek HelpIs It Safe To Travel? What To Consider Before Booking Your HolidayHow Can You Tell If You're Immune After Having The Covid Jab?Is It Safe To Travel? What To Consider Before Booking Your HolidayWhat The Indian Covid Variant Means For BritsHow The UK's Covid Traffic Light System Will Work
Latest News
Top news around the world
Coronavirus Disease

Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus.

Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people, and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness.

Around the World

Celebrity News

> Latest News in Media

Watch It
Devin Booker Avoids Kardashian Kurse As Him and Kendall Mark One Year Anniversary | TMZ TV
June 16, 2021
Byruw-y8CDs
Lil Pump Says Migos Definitely Belongs on Rap's Mt. Rushmore | TMZ
June 16, 2021
e9hnkhJZEQM
Drake, Future Party with Gunna at His Celeb-Packed 28th Birthday Bash | TMZ TV
June 16, 2021
JL_sya_rn0o
The Production Design Behind 'Dickinson': Blending Classic With Contemporary
June 16, 2021
mxKXM8nYp-g
Billy Porter & Uzo Aduba on ‘Pose,’ ‘In Treatment,’ and Reinventing Typecasts | Actors on Actors
June 16, 2021
phyozCD894A
Jean Smart & Bowen Yang on the 'Iceberg' Sketch, 'Hacks' and 'Watchmen' | Actors on Actors
June 16, 2021
GV1BrKFClXg
Padma Lakshmi’s new beau revealed to be writer Terrance Hayes | Page Six Celebrity News
June 16, 2021
8rMCC3vQTuE
Emily Ratajkowski’s crop top is a wardrobe malfunction waiting to happen | Page Six Celebrity News
June 16, 2021
_2cFIjD247I
Kelly Dodd, Braunwyn not returning to ‘Real Housewives of Orange County’ | Page Six Celebrity News
June 16, 2021
C9mbrK_FdZw
"How It Ends" Official Trailer
June 17, 2021
yk5oPPu--3M
Jana Kramer Is Focused on Healing, Her Kids & Sold Wedding Ring | Daily Pop | E! News
June 17, 2021
0IsQ3Qb5kHg
Victoria's Secret Clips Angel Wings & Rebrands With Priyanka Chopra | Daily Pop | E! News
June 17, 2021
o3IXFZBlBGQ
TV Schedule
Late Night Show
Watch the latest shows of U.S. top comedians

Sports

Latest sport results, news, videos, interviews and comments
Latest Events
19
Nov
ASIAN CHAMPIONS LEAGUE: Group H
Sydney FC - Shanghai SIPG
17
Nov
UEFA NATIONS LEAGUE A: Group Stage
Spain - Germany
14
Nov
UEFA NATIONS LEAGUE A: Group Stage
Germany - Ukraine
08
Nov
ENGLAND: Premier League
Manchester City - Liverpool
08
Nov
ENGLAND: Premier League
Arsenal - Aston Villa
08
Nov
SPAIN: La Liga
Valencia - Real Madrid
08
Nov
ITALY: Serie A
AC Milan - Verona
08
Nov
ENGLAND: Premier League
West Bromwich Albion - Tottenham Hotspur
08
Nov
ITALY: Serie A
Bologna - Napoli
08
Nov
ITALY: Serie A
Genoa - Roma
08
Nov
ITALY: Serie A
Atalanta - Inter Milan
08
Nov
ITALY: Serie A
Lazio - Juventus
08
Nov
GERMANY: Bundesliga
Bayer Leverkusen - Borussia Monchengladbach
08
Nov
ENGLAND: Premier League
Leicester City - Wolves
08
Nov
GERMANY: Bundesliga
Wolfsburg - Hoffenheim
08
Nov
SPAIN: La Liga
Real Valladolid - Athletic Bilbao
08
Nov
SPAIN: La Liga
Levante - Alaves
08
Nov
SPAIN: La Liga
Real Sociedad - Granada CF
08
Nov
ITALY: Serie A
Torino - Crotone
08
Nov
SPAIN: La Liga
Getafe - Villarreal
07
Nov
GERMANY: Bundesliga
Borussia Dortmund - Bayern Munich
07
Nov
ENGLAND: Premier League
Everton - Manchester United
07
Nov
ENGLAND: Premier League
Chelsea - Sheffield United
07
Nov
SPAIN: La Liga
Atletico Madrid - Cadiz
07
Nov
SPAIN: La Liga
Barcelona - Real Betis
07
Nov
GERMANY: Bundesliga
Augsburg - Hertha Berlin
07
Nov
GERMANY: Bundesliga
Stuttgart - Eintracht Frankfurt
07
Nov
GERMANY: Bundesliga
RB Leipzig - SC Freiburg
07
Nov
ENGLAND: Championship
Rotherham - Preston NE
07
Nov
ITALY: Serie A
Parma - Fiorentina
07
Nov
ENGLAND: Championship
Watford - Coventry
07
Nov
ENGLAND: Championship
Norwich City - Swansea City
07
Nov
ENGLAND: Championship
Blackburn - QPR
07
Nov
ENGLAND: Championship
Derby County - Barnsley
07
Nov
ENGLAND: Championship
Huddersfield - Luton
07
Nov
ENGLAND: Championship
Nottingham Forest - Wycombe Wanderers
07
Nov
ENGLAND: Premier League
West Ham United - Fulham
07
Nov
ENGLAND: Championship
Sheffield Wednesday - Millwall
07
Nov
ENGLAND: Championship
Brentford - Middlesbrough
07
Nov
ENGLAND: Championship
Birmingham - Bournemouth
07
Nov
SPAIN: La Liga
Sevilla - Osasuna
07
Nov
ITALY: Serie A
Benevento - Spezia
07
Nov
ENGLAND: Premier League
Crystal Palace - Leeds
04
Nov
CHAMPIONS LEAGUE: Group stage, Group G
Ferencvaros - Juventus
04
Nov
CHAMPIONS LEAGUE: Group stage, Group G
Barcelona - Dynamo K.
03
Nov
CHAMPIONS LEAGUE: Group stage, Group A
Salzburg - Bayern Munich
03
Nov
CHAMPIONS LEAGUE: Group stage, Group D
Atalanta - Liverpool
Find us on Instagram
at @feedimo to stay up to date with the latest.
Featured Video You Might Like
zWJ3MxW_HWA L1eLanNeZKg i1XRgbyUtOo -g9Qziqbif8 0vmRhiLHE2U JFCZUoa6MYE UfN5PCF5EUo 2PV55f3-UAg W3y9zuI_F64 -7qCxIccihU pQ9gcOoH9R8 g5MRDEXRk4k
Copyright © 2020 Feedimo. All Rights Reserved.